U.S. Treatment Guidelines: New Version, October 2005

Summary: The October 6, 2005 guidelines have relatively few changes, but they are important for some patients.

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The latest edition of the U.S. Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents was published October 6, 2005. For those beginning antiretrovirals, the guidelines now say that the combination of an NNRTI + didanosine plus tenofovir should not be used, due to virologic failure and development of resistance. And the guidelines do not recommend ritonavir-boosted tipranavir in treatment-naive patients, due to the lack of clinical-trial data.

For experienced patients, "This section has been updated to redefine the goal of antiretroviral therapy in the management of treatment-experienced patients with virologic failure and to review the role of more potent ritonavir-boosted protease inhibitors such as tipranavir with or without enfuvirtide in these patients."

Much of the guidelines material is presented in a series of tables. The second page, titled "What's New in the Document," also notes the tables that have been changed.

This and other U.S. government guidelines are available at
http://www.aidsinfo.nih.gov/guidelines/

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